ldn 57444 Search Results


mf 094  (Selleck Chemicals)
93
Selleck Chemicals mf 094
PR-619 DUB inhibitor decreased HIF2α protein level. (A) The list of DUB inhibitors in our study. DUB inhibitors including: ML323, ML364, EOAI3402143, XL117A, DUBs-IN-2, Spautin-1, IU1, GSK2643943, AZ1, <t>MF-094,</t> LDN-57444, TCID, PR-619, BAY117082, b-AP15. (B) EPAS1 gene status in OS-RC-2, 786-O, SW839, and ACHN, respectively. (C) HIF2α protein level was tested by WB after DUB inhibitors treatment in OS-RC-2 cells. (D) The effects of 5 candidate DUB inhibitors on HIF2α protein expression were further tested in 786-O and SW839 cells. HIF2α protein expression was tested by WB. Five candidate DUB inhibitors were ML364, DUBs-IN-2, GSK2643943, LDN-57444, and PR-619. DUB, deubiquitinating enzyme; HIF2α, hypoxia inducible factor 2α; WB, Western blotting.
Mf 094, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ldn+57444/pmc12968915-40-18-38?v=Selleck+Chemicals
Average 93 stars, based on 1 article reviews
mf 094 - by Bioz Stars, 2026-08
93/100 stars
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ldn treated animals  (Biosynth Carbosynth)
86
Biosynth Carbosynth ldn treated animals
PR-619 DUB inhibitor decreased HIF2α protein level. (A) The list of DUB inhibitors in our study. DUB inhibitors including: ML323, ML364, EOAI3402143, XL117A, DUBs-IN-2, Spautin-1, IU1, GSK2643943, AZ1, <t>MF-094,</t> LDN-57444, TCID, PR-619, BAY117082, b-AP15. (B) EPAS1 gene status in OS-RC-2, 786-O, SW839, and ACHN, respectively. (C) HIF2α protein level was tested by WB after DUB inhibitors treatment in OS-RC-2 cells. (D) The effects of 5 candidate DUB inhibitors on HIF2α protein expression were further tested in 786-O and SW839 cells. HIF2α protein expression was tested by WB. Five candidate DUB inhibitors were ML364, DUBs-IN-2, GSK2643943, LDN-57444, and PR-619. DUB, deubiquitinating enzyme; HIF2α, hypoxia inducible factor 2α; WB, Western blotting.
Ldn Treated Animals, supplied by Biosynth Carbosynth, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ldn+57444/pmc03262074-149-13-21?v=Biosynth+Carbosynth
Average 86 stars, based on 1 article reviews
ldn treated animals - by Bioz Stars, 2026-08
86/100 stars
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ldn 57444  (BPS Bioscience)
N/A
LDN 57444 is a cell permeable ubiquitin C terminal hydrolase UCH L1 inhibitor Ki 0 4 µM Decreases proteasome activity and increases levels of ubiquitinated proteins Induces apoptosis and causes dramatic alterations in synaptic protein
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ldn-57444  (Aladdin Scientific Corporation)
N/A
LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.A potent, reversible, active site-directed UCH-L1 inhibitor
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ldn-57444  (StressMarq)
N/A
DUB inhibitor
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ldn-57444  (BPS Bioscience)
N/A
LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 µM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in
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ldn 57444  (Tocris)
N/A
Ubiquitin C terminal hydrolase L1 UCH L1 inhibitor
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ldn-57444  (BOC Sciences)
N/A
LDN-57444 is a reversible, competitive proteasome inhibitor for UCH-L1 with IC50 of 0.88 μM, 28-fold greater selectivity over isoform UCH-L3.
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ldn-57444  (MedChemExpress)
N/A
LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC50 of
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ldn 57444  (Cayman Chemical)
N/A
The ubiquitin C terminal hydrolase L1 UCH L1 is a member of a family of de ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity By associating with free
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ldn-57444  (TargetMol)
N/A
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Image Search Results


PR-619 DUB inhibitor decreased HIF2α protein level. (A) The list of DUB inhibitors in our study. DUB inhibitors including: ML323, ML364, EOAI3402143, XL117A, DUBs-IN-2, Spautin-1, IU1, GSK2643943, AZ1, MF-094, LDN-57444, TCID, PR-619, BAY117082, b-AP15. (B) EPAS1 gene status in OS-RC-2, 786-O, SW839, and ACHN, respectively. (C) HIF2α protein level was tested by WB after DUB inhibitors treatment in OS-RC-2 cells. (D) The effects of 5 candidate DUB inhibitors on HIF2α protein expression were further tested in 786-O and SW839 cells. HIF2α protein expression was tested by WB. Five candidate DUB inhibitors were ML364, DUBs-IN-2, GSK2643943, LDN-57444, and PR-619. DUB, deubiquitinating enzyme; HIF2α, hypoxia inducible factor 2α; WB, Western blotting.

Journal: Translational Andrology and Urology

Article Title: USP10 regulates HIF2α stability by deubiquitinating HIF2α regardless of VHL status in kidney cancer

doi: 10.21037/tau-2025-aw-778

Figure Lengend Snippet: PR-619 DUB inhibitor decreased HIF2α protein level. (A) The list of DUB inhibitors in our study. DUB inhibitors including: ML323, ML364, EOAI3402143, XL117A, DUBs-IN-2, Spautin-1, IU1, GSK2643943, AZ1, MF-094, LDN-57444, TCID, PR-619, BAY117082, b-AP15. (B) EPAS1 gene status in OS-RC-2, 786-O, SW839, and ACHN, respectively. (C) HIF2α protein level was tested by WB after DUB inhibitors treatment in OS-RC-2 cells. (D) The effects of 5 candidate DUB inhibitors on HIF2α protein expression were further tested in 786-O and SW839 cells. HIF2α protein expression was tested by WB. Five candidate DUB inhibitors were ML364, DUBs-IN-2, GSK2643943, LDN-57444, and PR-619. DUB, deubiquitinating enzyme; HIF2α, hypoxia inducible factor 2α; WB, Western blotting.

Article Snippet: ML323 (cat#S7529), ML364 (cat#S6748), EOAI3402143 (cat#S6877), XL117A (cat#S8967), DUBs-IN-2 (cat#E0389); Spautin-1 (cat#S7888), IU1 (cat#S7134), GSK2643943 (cat#S6878), AZ1 (cat#S8904), MF-094 (cat#E1098), LDN-57444 (cat#S7135), TCID (cat#S7140), PR-619 (cat#S7130), BAY 11-7082 (cat#S2913), b-AP15 (cat#S4920), and MG132 (cat#S2619) were all purchased from Selleckchem (Shanghai, China).

Techniques: Expressing, Western Blot